In Spiters Annihilation, it's your job to kill annoying purple monsters called spiters. You must eliminate all of the spiters in each level with the available tools. Use hammers to destroy glass objects, attach balloons to the spiters to make them float, and place various items on the screen to complete your task. You can kill the spiters by piercing them with spikes, blowing them up with bombs, or squishing them with heavy objects.