Frank N Slime is a puzzle platformer that uses a humorous voice-over narration to accompany its 28 levels. As usual, you must figure out how to reach the exit in each level. The levels are wraparound, which means that moving past the edge of the screen will transport you to the opposite side of the stage. The puzzles start off simple, but become more challenging as spikes, crates, buttons, and the ability to teleport are introduced.